Perio Reports Vol. 24, No. 6 |
Perio Reports provides easy-to-read research summaries on topics of specific interest to clinicians.
Perio Reports research summaries will be included in each issue to keep you on the cutting edge
of dental hygiene science.
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Health Benefits of Xylitol Recognized by AAPD
The American Academy of Pediatric Dentistry (AAPD)
recognizes the caries preventive benefits of xylitol. Its policy,
based on current scientific research, assists dental professionals
in making informed decisions on the use of xylitol products
for caries prevention. The original xylitol policy was
adopted in 2006, with this update in 2010.
A total of 240 articles were reviewed pertaining specifically
to xylitol use for caries prevention, with 25 reviewed
for the 2010 update.
The dental benefits of xylitol were first recognized in
Finland in 1970. In 1975, the first xylitol-sweetened chewing
gum was developed. The Turku Sugar Studies were the
first xylitol studies in humans showing a relationship
between dental plaque and xylitol. Early studies comparing
sucrose-sweetened to xylitol-sweetened chewing gum
reported caries rates one-third as high in the xylitol group
compared to the sucrose group.
A long-term study published in 1995 comparing xylitol,
sorbitol and sucrose consumption revealed lower plaque
scores and lower levels of salivary bacteria in the xylitol group.
Studies suggest xylitol consistently produces positive
results with 4-10 grams per day divided into three to
seven exposures. Higher daily intake doesn’t provide
advantages, while frequency of less than three exposures
provides no benefit.
Benefits of daily xylitol consumption include reduced
plaque formation, reduced bacterial adherence and prevention
of enamel demineralization. Long-term effects demonstrated
benefits at five years after xylitol-sweetened chewing
gum. Xylitol currently is available in many forms: gums,
mints, chewable tablets, lozenges, toothpastes, mouthwashes,
cough mixtures and nutraceutical products. Other
xylitol products are being studied.
Clinical Implications: The AAPD supports
the use of xylitol as part of a preventive
strategy.
AAPD Council on Clinical Affairs. Policy on the use of xylitol in Caries
Prevention. Pediatr Dent 33: 6, 42-22, 2010.
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Xylitol Prevents Transmission of Bacteria from Mother to Child
Xylitol is a five-carbon, natural sugar that does not contribute
to caries. Daily oral consumption of xylitol appears to
interfere with the adhesion properties of Mutans streptococci
(MS) bacteria. In other words, MS sheds easily from plaque
into saliva.
Researchers in Finland compared 169 mother-child pairs
to determine if the transmission of MS mothers to infants
could be prevented with the mothers’ daily consumption of
xylitol. The mothers were assigned to one of three groups:
xylitol chewing gum three times daily, chlorhexidine varnish
or fluoride varnish. The varnishes were applied every six
months over the two-year study period.
Baseline data was taken during pregnancy and all mothers
showed high salivary levels of MS. The 106 mothers in the xylitol
group began chewing xylitol-sweetened gum three months
after delivery of their babies. There were 66 women in the two
varnish groups. The children received no treatment. MS were
measured in the mothers’ saliva every six months for two years.
The mothers’ salivary MS levels remained high among
the three study groups throughout the study. At two years of
age, the MS transmission from mothers to children was lowest
in the xylitol group, 9.7 percent of children had MS in
saliva, compared to 29 percent in the chlorhexidine varnish
group and 49 percent in the fluoride varnish group.
Clinical Implications: A mother’s use of xylitol chewing gum during the first two years of their child’s life will reduce
MS transmission to the child’s mouth.
Söderling, E., Isokangas, P., Pienikäkkinen, K., Tenovuo, J.: Influence of Maternal Xylitol Consumption on Acquisition of Mutans Streptococci by Infants. J Dent Res, 79:3, 882-887, 2000. |
Oral Probiotics Reduce Cariogenic Bacteria in Children
Two over-the-counter oral probiotics are now available
to control cariogenic bacteria: PerioBalance by Sunstar
Butler and EvoraKids by Oragenics. PerioBalance
uses Lactobacilli reuteri and EvoraKids uses
ProBiora3, a blend of Streptococcus oralis,
Streptococcus uberis and Streptococcus rattus.
Researchers at Children’s Memorial Hospital
in Chicago, Illinois, tested PerioBalance and
EvoraKids on children found to be at moderate
to high caries risk using a caries risk assessment
system (CAMBRA). The 60 children involved in
this study were ages six to 12. The oral probiotic
lozenges were taken daily for 28 days.
Baseline saliva samples were collected and the
Caries Risk Test (CRT) from Ivoclar was used to measure
Strep mutans (SM) and Lactobacilli. The process of the CRT
incubates saliva samples applied to two agar carriers placed
in an incubator for 48 hours. SM grow blue colonies on the
agar carrier and Lactobacilli grow white colonies. The CRT
was repeated at six to eight weeks.
Both test groups showed significant reductions in the
number of colony-forming units of oral bacteria from baseline
to end of study. PerioBalance SM values were reduced
-6.78 and Lactobacilli -5.762. EvoraKids SM values were
reduced -7.33 and Lactobacilli -2.952.
Clinical Implications: Over-the-counter oral probiotics
are effective in decreasing cariogenic bacteria in children
found to be at moderate to high risk of caries.
Cannon, M., Walsh, B., Vorachek, A., Kramer, S., Esterly, R.: DNA-PCR and CRT Results in Children
After Probiotic Use. J Dent Res, Abstract 9, 2012.
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Oral Probiotics and Experimental Gingivitis
Oral probiotics in the form of mints or chewing
gums introduce healthy bacteria to the oral
cavity. The goal is to change the balance of the
oral flora to one of health. Lactobacillus reuteri
(L. reuteri) colonizes the intestines of healthy
humans. It was isolated in the 1960 by microbiologist
Gerhard Reuter, after whom it was later
named. L. Reuteri produces an antibiotic substance
that can kill harmful oral bacteria causing
caries or periodontitis.
Researchers at the University of Texas in
Houston wanted to know if introducing an oral probiotic
when subjects performed no oral hygiene would
prevent experimental gingivitis. A group of 53 adults
participated in this study. Baseline data included gingival
index, plaque index and unstimulated saliva to test
for bacteria. All subjects received a prophylaxis and were
instructed to refrain from all oral hygiene for two weeks
and chew their assigned gum once daily. The test group
of 26 subjects was given chewing gum containing L.
reuteri, and the control group of 27 subjects was given
the placebo chewing gum. Both subjects and examiners
were blinded to group assignments.
At two weeks and four weeks both groups showed
significantly increased plaque levels and gingivitis scores.
There were no differences between groups for these clinical
indices. Saliva samples from all subjects in the control
group tested negative for the presence of L. Reuteri.
In the test group, 40 percent of saliva samples tested
positive for the presence of L. reuteri.
Clinical Implications: A probiotic chewing gum
can introduce and promote colonization of good
bacteria, but once daily is not enough to prevent
experimental gingivitis.
Tran, L., Flaitz, C., Rigney, T., Tribble, G., Katancik, J.: The Effects of the Probiotic,
Lactobacillus reuteri, on Experimental Gingivitis. J Dent Res, Abstract 1533, 2012. |
Comparison of Water Flosser and Air Floss
New alternatives are needed for cleaning
between the teeth, since compliance with dental
flossing with string floss is so low. Flossing with
water has been available for many
decades from WaterPik and a new
interdental cleaning device is now
available from Philips Sonicare,
the Air Floss. This device combines
a puff of air with a small
amount of water directed between
the teeth.
Researchers at BioSci Research
in Canada compared the WaterPik
Water Flosser and the Philips
Sonicare Air Floss in a group of
82 subjects over four weeks. All
subjects used a manual toothbrush
plus their assigned irrigation
device. Instructions were both written and verbal
and were repeated at two weeks. Gingivitis, bleeding
and plaque scores were recorded at baseline, two
weeks and four weeks.
At two weeks and four weeks, both groups
showed significant clinical improvement compared
to baseline. Those using the Water Flosser demonstrated
significantly more effective reductions in
both plaque and gingivitis at week two and week
four in all areas measured. At the end of the study,
gingivitis was reduced more in the Water Flosser
group compared to the Air Floss group. At four
weeks, full-mouth plaque levels were 51 percent in
the Air Floss group compared to 30 percent in the
Water Floss group. For the air floss group, plaque
levels were higher on approximal surfaces, 77 percent
compared to 48 percent, and 53 percent on
facial surfaces compared to 36 percent.
Clinical Implications: The Water Flosser is more
effective for plaque removal and reducing gingivitis
than the Air Flosser.
Sharma, N., Lyle, D., Qaqish, J., Schuller, R.: Comparison of two power interdental cleaning
devices on the reduction of gingivitis. J Clin Dent 23:1, 22-26, 2012.
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Tongue Cleaning Reduces Bad Breath
Everyone has bad breath sometimes, and some people
have chronic bad breath all the time, from 25 to 50 percent,
depending on the population. Morning bad breath is due to
overnight dryness when saliva flow is at it lowest, enhancing
the growth of oral bacteria. Bacterial biofilm accumulates on
and around the teeth, and is also part of tongue coating,
especially on the dorsum of the tongue. Eating and drinking
in the morning tends to eliminate overnight bad breath, but
sometimes it is a chronic problem.
Ninety percent of bad breath can be attributed to oral
causes including caries, periodontal disease, poor oral
hygiene and tongue coating. The gold standard of measuring
bad breath is organoleptic testing or smelling the person’s
breath. It is also measured by the level of unpleasantsmelling
volatile sulfur compounds (VSC) in the mouth air.
Researchers at three universities in The Netherlands
reviewed the research to determine if tongue cleaning with a
scraper or toothbrush in addition to regular oral hygiene
would reduce oral malodor. Of the 405 studies and abstracts
their search produced, 22 full-text articles were read and 17
of these were excluded as they didn’t match the established
criteria they were looking for in the studies. The five studies
that did fit all criteria were evaluated and compared, showing
that tongue scraping or brushing does reduce oral malodor.
These studies did not evaluate chronic bad breath.
Clinical Implications: Results of this systematic review suggest that cleaning the dorsum of the tongue with a scraper
or brush will reduce oral malodor.
Van der Sleen, M., Slot, D., Van Trijffel, E., Winkel, E., Van der Weijden, G.: Effectiveness of Mechanical Tongue Cleaning on Breath Odour and Tongue Coating: A Systemic Review. Int J Dent Hygiene 8:
258-268, 2010. |